How To Test ketamine

Ketamine Testing Instructions

How to test ketamine: If you intend to use ketamine, it is important to understand what ketamine is, its effects, and how to practice harm reduction.  A safety and harm reduction guide for ketamine can be found HERE.  Next, you must obtain a ketamine test kit to check for adulterants. Ketamine is impossible to be visually identified and therefore you must use reagents.  Ketamine is typically seen as a white or off-white  powder and it may occasionally be found in illicit markets sold as a liquid.  It is recommended to test all ketamine with Mandelin, Mecke, Liebermann, and Froehde.  More than ever, it is also important to test for the presence of fentanyl and its analogs with our fentanyl test strips.

It is important to understand that drug reagent tests are presumptive tests that indicate PRESENCE, but not PURITY or QUANTITY of any substance. By using multiple reagent tests, the accuracy and detection of adulterants drastically increases.

REMEMBER: A positive or negative test result does not indicate if the substance is safe. No substance is 100% safe. 


Ketamine Chart



We recommend video recording the reactions of all testing results.  In this way, you can always review the results later.


Ketamine Flow Chart

STEP ONE: Primary Test for Ketamine

  • Take a sample about the size of a grain of sand and crush it into a fine powder.
  • If you do not have a spot test plate, place your sample on the bottom of a white ceramic plate or coffee mug. Do not use paper plates or any other surfaces as the test kits are highly corrosive and will destroy the surface and ruin your test sample.  You may use the included single-use testing vials.
  • Add one drop of the Mandelin Reagent Test (Primary) on the sample and wait up to 60 seconds for the results.
  • Compare the reagent test results to the provided color chart.


  • To compare the test results, start with the Mandelin Test Kit: for ketamine, the color change reaction should quickly turn from orange to brown.


STEP TWO: Testing Ketamine for Adulterants  

After you have confirmed the presence of ketamine, it is important to test for adulterants.  Repeat the testing steps from above with each of the additional reagents listed below and compare to the color charts.  The most common adulterants for Ketamine are caffeine, creatine and novel dissociatives.

  • There are several reagents that should NOT change color with ketamine including Marquis, Mecke, & Froehde.
  • Liebermann can be used and will turn a very pale yellow color change for ketamine.
  • It should be noted that non-active cutting agents can impact the reagent tests results.


  • To neutralize the reagents and any testing surfaces, a combination of baking soda and water can be used.
  • If baking soda is not available, thoroughly rinse all testing surfaces with plenty of running water.
  • Wash hands and make sure all reagents are safely stored according to the instructions.


Choose the right reagents

There are several options to help keep you safe. From a single reagent to a full kit, we have what you need.

Frequently asked questions

It is typical that synthetic drugs in a form of salt will fizz and bubble with most reagent tests.  Reagents are strong acids and react to strong bases.  If you see only fizzing instead of color change, that can indicate presence of a new psychoactive substance.

The reaction speed does not indicate specific quantity nor purity. Results should be read at 60 seconds.

All of our bottles are good for about 200 tests (10 ml). Remember, for each test, only use one drop.

Our reagents are specifically bottled in glass bottles to increase shelf life. Reagents are strong acids and contact with plastics will degrade them significantly faster.  Always store your reagents in a cool, dark place.